GCT-Combo

Sane Science Nutritions

Taurine helps to improve performance by synergising muscle contraction thus power
Taurine also appears to be essential for normal contraction of skeletal muscle

Taurine is an amino sulfonic acid, but it is often referred to as an amino acid
Some scientist believes that Taurine is one of the most abundant amino acids in the brain and spinal cord, leukocytes, heart and muscle cells, the retina, and indeed almost every tissue throughout the body
Because it is one of the few amino acids not used in protein synthesis, taurine is often referred to as a “nonessential” amino acid, or more generously as a “conditionally essential” amino acid.
Considering its broad distribution, its many cytoprotective attributes, and its functional significance in cell development, nutrition, and survival, these are clearly misnomers. Taurine is undoubtedly one of the most essential substances in the body
Taurine is a broad-spectrum cytoprotective agent and has functional significance in cell development, nutrition, and survival.
Taurine plays a role in the modulation of intracellular free calcium concentration.
Taurine supplementation can inhibit light-induced lipid peroxidation
Taurine plays a significant role in overcoming insulin resistance
Taurine restore glucose metabolizing enzyme activities and improve insulin sensitivity by modifying the post-receptor events of insulin action
Taurine has proven essential for normal development
Taurine also plays a critical role in brain development
Taurine has ability to improve mitochondrial function by stabilizing the electron transport chain and inhibiting the generation of reactive oxygen species thus shows potent anti-oxidant activity.
There is ever-increasing evidence that taurine depletion leads to a wide range of pathological conditions, including severe cardiomyopathy, renal dysfunction, pancreatic β cell malfunction, and loss of retinal photoreceptors
The regulation of calcium homeostasis by taurine has been extensively studied although many of the studies examined the effect of extracellular taurine on both contractile function and [Ca2+]
Taurine can increase Ca2+ sensitivity of contractile proteins and alter tension development.
Administration of taurine also improves physical endurance

Osmo-regulatory activity of Taurine: heart and muscle Cells do not tolerate extreme alterations in cell size, therefore, they possess volume regulatory mechanisms to counteract the consequences of osmotic stress and normalize cell volume. Changes in taurine uptake and release contribute to the normalization of cell volume in most cell types. In the case of heart and muscle the turnover of taurine is normally very slow. Yet myocyte taurine content can be dramatically altered by changes in osmotic stress.
Using a skinned fiber preparation containing permeabilized cell membrane, Steele et al. and Galler et al. provided the first evidence that physiological concentrations of taurine can increase Ca2+ sensitivity of contractile proteins and alter tension development. These effects of taurine were attributed to the modulation of sarcoplasmic reticular Ca2+ release, with the effect greater in preparations containing Ca2+ deficient sarcoplasmic reticulum, but less when the sarcoplasmic reticulum contain a high Ca2+ load. In contrast, acute taurine elevations exert no apparent effect on Ca2+ uptake by enriched sarcoplasmic reticular preparations. However, the acute taurine studies do not rule out a role of the sarcoplasmic reticular Ca2+ pump in the chronic actions of taurine. Indeed, in vivo chronic taurine influences the activity of the sarcoplasmic reticular Ca2+ ATPase through at least two factors that are altered by taurine.

First, recent evidence reveals that the phosphorylation of the sarcoplasmic reticular phosphoprotein, phospholamban is reduced in the taurine deficient heart. Because the phosphorylation of phospholamban enhances the rate of Ca2+ uptake by the sarcoplasmic reticulum, it increases the rate of myocardial relaxation. Second, there is an extensive literature touting the “antioxidant” activity of taurine. According to Park et al. the activity of the sarcoplasmic reticular Ca2+ ATPase is inhibited by oxidative stress. It is known that sarcoplasmic reticular Ca2+ uptake and Ca2+-induced Ca2+ release play key roles in regulating [Ca2+]i and modulating Ca2+ delivery and removal from the muscle proteins. Moreover, the binding of Ca2+ to troponin determines the response of the muscle proteins to elevated [Ca2+]i. Therefore, it is not surprising that taurine is required for normal systolic and in diastolic function.

Taurine also appears to be essential for normal contraction of skeletal muscle. Warskulat et al. found that skeletal muscle function is severely impaired in taurine transporter knockout mice. Interestingly, physical exercise decreases taurine levels of skeletal muscle, an effect partially prevented by taurine administration.Administration of taurine also improves physical endurance. In accordance with the actions of taurine in the heart, Bakker and Berg reported that the effects

Recommended Dose: 15g (Half Scoop)
Flavours: Tangy Orange
Packing : 450 g MRP: Rs. 1280
Serving Size: 1 Scoop of approx 15 gm

How to use : GTC is ideal support before and during exercise. You can take it 15 min prior to exercise for protect your body from catabolism and pump more power to your muscles. In case of long bouts of exercise when you feel low, you can take GCT to improve your recovery and get muscles refilled.

Warning: Consult your dietician for optimum uses, do not exceed recommended dose. All claims are based on various studies and data available on internet, books & journals and not verified by any authority, or FSSAI.

GCT Combo - Glutamine + Creatine + Taurine with Polysacchrides

Protection Power Performance
GTC is perfect blend of important nutrients that protects from muscle catabolism; maintain energy level for long lasting exercise and boost contractile power of muscles thus ensure best performance.

Scientific formulation of GCT contains well balanced blend of Glutamine, Creatine and Taurine with complex carbohydrate. The ideal formulation of GCT sustains your performance incrase power and protects your muscles. GCT is ideal supplement to protect from over training syndrome (OTS) which is result of high intensity exercise or training. Over training can leads to serious medical problems and can keep you out of exercise or training. Over training is main culprit for poor performance. GCT helps you to overcome over training syndrome as glutamine protects your muscles as well as improves immunity, creatine alongwith polymer glucose helps in faster recovery and taurine helps to maintain contractile ability of muscles thus you are ready for next bout of your training.

Possible Health Benefits
Why GCT is useful for Protection of muscles from catabolism

GCT contains Glutamine which is well established anti-catabolic amino acid.
Glutamine is the most abundant extracellular amino acid. The physiological importance of the amino acid L-glutamine for promoting and maintaining cell function is widely accepted
Large number of tissues and cells of the body utilize glutamine at high rates and that glutamine utilization is essential for their function. These tissues and cells include kidney, intestine, liver, specific neurons in the CNS, cells of the immune system and pancreatic b-cells
Glutamate appears to be at the crossroads of amino acid metabolism, where it can donate its amino group for new amino acid synthesis (transamination)
Glutamine is important as a precursor for peptide and protein synthesis, amino sugar synthesis, purine and pyrimidine and thus nucleic acid and nucleotide synthesis, as well as providing a source of carbons for oxidation in some cells
The store of free glutamine within the skeletal muscle is considerable, estimated at 20 mmol/L of intracellular water, which accounts for the majority of the body’s total glutamine stores
Skeletal muscle is the primary source of glutamine released to the bloodstream which may play an important role in delivering glutamine to the immune system
An intense bout of exercise (heavy workload resistance training, marathon, prolonged cycling) are called as “stressful event”. During exercise, increases and decreases in plasma glutamine levels have been demonstrated and these variations are reflected upon the type, duration, and intensity of exercise.
16 randomized, blind, controlled clinical trials results proves that during periods of catabolic stress, plasma glutamine levels are depressed and muscle wasting occurs.
A number of studies have shown decrease in plasma glutamine level following high intensity exercise. This causes delay in recovery and leading an individual into an over-trained state and develops Over Training Syndrome (OTS), which leads to recurrent infections; fatigue, impaired immune function, and reduced exercise performance have been observed
Glutamine supplementation stimulates faster recovery time, prevent OTS, and allow an individual to participate in multiple bouts of exercise more frequently and prolonging time to fatigue.
Evidence says that glutamine supplementation shows beneficial effects on exercise performance
Supplementation of glutamine may be decrease the severity of the inflammatory response, resulting in less muscle damage and possibly enhancing muscle recovery.
The major transmitters at excitatory synapses in the central nervous system are glutamate and acetylcholine
L-glutamine appears to play a major role in protecting the integrity of the gastrointestinal tract.
Reverse the catabolic state by sparing skeletal muscle L-glutamine.
L-glutamine helps maintain secretory IgA, which functions primarily by preventing the attachment of bacteria to mucosal cells.
L-glutamine appears to be required to support the proliferation of mitogen-stimulated lymphocytes, as well as the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma).
It is also required for the maintenance of lymphokine-activated killer cells (LAK).
L-glutamine can enhance phagocytosis by neutrophils and monocytes.
It can lead to an increased synthesis of glutathione in the intestine, which may also play a role in maintaining the integrity of the intestinal mucosa by ameliorating oxidative stress.
Like other amino acids, glutamine is biochemically important as a constituent of proteins. Glutamine is also crucial in nitrogen metabolism. Ammonia (formed by nitrogen fixation) is assimilated into organic compounds by converting glutamic acid to glutamine.
Doses of L-glutamine up to 21 grams daily appear to be well tolerated. Reported adverse reactions are mainly gastrointestinal and not common. They include constipation and bloating.

How creatine helps to improve power
Power is result of force of muscle contraction which is energy dependent. Creatine plays vital role in energy release thus helps to increase force of contraction so more power.

Creatine is an example of a physiologically important nitrogenous compound synthesized from amino acids.
Muscular contraction results in an accumulation of Cr because creatine plays an important role in the transfer of energy.
Cr depends on various dietary factors and body can conserve the dietary essential amino acids, arginine and methionine, during times of dietary insufficiency or stress.
Growth hormone and thyroid hormone deficiency decrease AGAT (Enzyme that plays chief role in creatine synthesis) activity, thus decreases creatine synthesis
Limitations in Cr synthesis might exist during conditions of folic acid and/or vitamin B 12 deficiencies
Testosterone stimulates AGAT expression and thus, Cr biosynthesis. The rate of Cr biosynthesis is on the order of 1-2 g/d.

How creatine helps in exercise and recovery

Exercise results in high demand of ATP which rapidly depleted and gives ADP and give required energy to muscle contraction
Exercise: ATP ---(ATPase)---> ADP + Pi

High energy demand leads to depletion of ATP in muscle cell and creatine comes in metabolism to give energy for muscle contraction thus creatine depletes from cells
Exercise: PCr + ADP + H + ---(CK)--->Cr + ATP

Creatine, in the form of PCr, is essential for replenishing ATP stores that are used immediately during high-intensity exercise & PCr is depleted very quickly. During recovery period if creatine is available in diet, faster creatine replenishment ensure faster recovery.
Recovery: PCr + ADP + H + <---(CK)---Cr + ATP

Studies have shown that prior creatine loading enhances glycogen storage and carbohydrate loading in a trained muscle, new research has shown that creatine can help buffer lactic acid that builds-up in the muscles during exercise and helps in faster recovery

Improving the status of skeletal muscle-PCr stores through Cr ingestion can help delay PCr depletion and rapidly refresh stores of ATP to prevent the occurrence of fatigue during short-term muscular effort
Reduces dependence on anaerobic glycolysis for energy production and reduces lactic acid formation.
Helps muscle relaxation and recovery during repeated bouts of intense, short duration effort through increased rate of ATP and PCr resynthesis, thus allowing for continued high power outputs
From the liver, Cr can be exported and transported throughout the bloodstream and taken up by Cr-requiring tissues, such as skeletal muscle, heart, and brain
Dietary Cr has a very high bioavailability, passing through the digestive tract intact for transport directly into the bloodstream.
Normal plasma levels of Cr are about 50 mmol/L, and increase sharply after supplementation with Cr or ingestion of meat.
Research with food and supplement sources of Cr has shown that consuming 2 g of Cr in solution resulted in a peak plasma concentration of nearly 400 mmol/L at 30-60 min.
Once absorbed into the bloodstream, Cr (from both endogenous and dietary sources) is either cleared by the kidneys or taken up at the tissue level, primarily skeletal muscle, to be used.
With respect to dietary Cr. not all of the ingested Cr can be retained in the body once absorbed, especially when high doses of supplements are taken. A high proportion of Cr is usually retained in the initial days of Cr supplementation, but urinary Cr excretion progressively increases with continued ingestion.
An explanation for the decrease in Cr retention with high-dose supplementation may be owing to the observation that, Cr supplementation can result in downregulation of the Cr transporter (CreaT) isoform expression in skeletal muscle. In other words, there are less CreaT receptors in muscle after supplementing with Cr. This effect on CreaT receptors is probably one reason why there appears to be a limit or maximal amount of Cr that can be stored
Cr accumulation might be increased slightly by ingesting insulin stimulating nutrients such as carbohydrate. Cr supplementation combined with 1 g glucose/kg body mass twice per day increased muscle total-Cr by 9% more than Cr supplementation alone.
Cr uptake has been shown to be stimulated following submaximal exercise bouts.
This increase in Cr uptake following exercise has been demonstrated to only occur in skeletal muscles involved in the exercise.
Enhances the performance
Increase lean body mass, strength, and total work
Increase anaerobic work capacity
Helps in protein synthesis for greater muscles gain
Remove lactic acid from muscles after intense workout.
Improves cognition and brain function
Increase bone density
Enhances glycogen storage and carbohydrate loading